• Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage

    Optimal blood pressure management for intracerebral hemorrhage (ICH) patients remains unclear. In a prospective randomized clinical trial, patients with ICH volume <60 cm3 and Glasgow Coma Scale (GCS) score of >5 were randomized to a systolic blood pressure of 110-139 mm Hg (intensive treatment) or 140-179 mm Hg (standard treatment).  In 1000 participants with a mean (±SD) systolic admission blood pressure of 200.6±27.0 mm Hg, 500 were assigned to intensive treatment and 500 to standard treatment.  Enrollment was stopped after a pre-specified interim analysis. The primary outcome of death or disability was observed in 38.7% (186 of 481) of the intensive treatment group and in 37.7% (181 of 480) of the standard treatment group.  1.6% of the intensive treatment patients and 1.2% of the standard treatment group had serious adverse events occurring within 72 hours after randomization that were considered by investigators as treatment-related, but the renal complication rate was higher in the intensive treatment cohort. This trial does not support an acute systolic blood pressure goal of 110-139 mm Hg in ICH patients.


    New England Journal of Medecine

We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site here. Privacy Policy