Cavernous malformation hemorrhage rates have classically been derived from a mixture of symptomatic and asymptomatic lesions. In order to determine the prospective hemorrhage rate, Moore and co-authors present the longest follow-up of asymptomatic intracerebral cavernomas. 1311 patient-years of follow-up for 107 patients diagnosed between 1989 and 1999 (49.5% male; mean age at diagnosis 52 years) were available for this cohort of incidentally found cavernomas. The prospective bleed rate was 0.08% per patient-year. No new seizures developed in these patients during follow-up. This study shows that the prospective hemorrhage and seizure risks in patients presenting with asymptomatic cavernomas are very low, and aids managment decisions for these patients.
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