• Restenosis & risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study: secondary analysis of a RCT

    The International Carotid Stenting Study examined 1713 patients across 50 centers with symptomatic carotid stenosis (50% or greater) who were randomized to angioplasty and stenting vs endarterectomy in a 1:1 ratio.  Patients were followed at 30 days, 6 months, and annually for 10 years with carotid Doppler studies.  In the 1530 patients with adequate follow-up, 5-year cumulative risk of at least moderate restenosis (> 50%) was 40.7% after stenting and 29.6% in endarterectomy patients (p<0.0001).  No significant difference was seen in the frequency of severe restenosis (>70%), occurring in 10.6% of the stented patients and 8.5% of the endarterectomy patients.  In both treatment groups combined, patients with at least 50% restenosis were at a higher 6-year risk of ipsilateral stroke (6.9% vs 2.5% p=0.002), though increased risk of stroke with restenosis in the stenting group alone did not reach significance (7.8% vs 3.8%, p=0.154).  There was no significant difference in the 6-year risk of ipsilateral stroke between interventions.  This study provides evidence that long term follow up is indicated following stenting and endarterectomy for carotid stenosis.


    Lancet Neurology

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